Curcumin (Longvida)
Four randomized, placebo-controlled trials have tested Longvida on cognition. Two from the same research group were positive at 400mg/day: in 60 healthy adults aged 60–85 (Cox et al., 2015), sustained attention and working memory improved 1 hour after a single dose, and working memory and mood after 4 weeks; in 80 adults aged 50–80 (Cox et al., 2020, funded by Longvida's maker Verdure Sciences), working memory was better at 12 weeks and fatigue lower at 4 and 12 weeks. Two trials funded by the US National Institutes of Health, with capsules supplied by Verdure Sciences, gave 2000mg/day and found no cognitive benefit: 12 weeks in 39 healthy adults aged 45–74 (Santos-Parker et al., 2018) and 12 months in 88 adults with chronic kidney disease (Gimblet et al., 2024). The positive results have not been repeated by an independent group.
Evidencia revisada el
Mecanismo de acción
Longvida is Verdure Sciences' trademarked solid lipid curcumin particle (SLCP) formulation of curcumin, the main active compound in turmeric (Curcuma longa). A 400mg dose of Longvida provides about 80mg of curcumin, so doses given as mg of Longvida and mg of curcumin differ about five-fold. Curcumin has properties in preclinical studies that may act on processes behind age-related cognitive decline, but those benefits had not been established in humans when the Longvida trials began; the trials measured cognitive and mood outcomes, not how they might arise.
Resumen de evidencia clínica
Four randomized, placebo-controlled trials have tested Longvida on cognition. Two from the same research group were positive at 400mg/day: in 60 healthy adults aged 60–85 (Cox et al., 2015), sustained attention and working memory improved 1 hour after a single dose, and working memory and mood after 4 weeks; in 80 adults aged 50–80 (Cox et al., 2020, funded by Longvida's maker Verdure Sciences), working memory was better at 12 weeks and fatigue lower at 4 and 12 weeks. Two trials funded by the US National Institutes of Health, with capsules supplied by Verdure Sciences, gave 2000mg/day and found no cognitive benefit: 12 weeks in 39 healthy adults aged 45–74 (Santos-Parker et al., 2018) and 12 months in 88 adults with chronic kidney disease (Gimblet et al., 2024). The positive results have not been repeated by an independent group.
Matriz de efectos en humanos
Based on human clinical trials only. Animal and in-vitro data excluded.
| Efecto | Evidencia | Magnitud | Estudios |
|---|---|---|---|
| Working Memory | mixed | Pequeño | 4 |
| Fatigue & Mood | preliminary | Pequeño | 2 |
| Acute Attention | preliminary | Pequeño | 1 |
Evidence key: Strong = multiple consistent RCTs · Moderate = smaller/fewer RCTs · Preliminary = early trials or small n · Mixed = conflicting results
Beneficios documentados
- Better working memory in healthy older adults at 400mg/day (two trials from one research group)
- Lower fatigue at 4 and 12 weeks (one trial)
- Better attention and working memory 1 hour after a single dose (one trial)
Efectos secundarios y precauciones
- Fasting blood glucose was slightly higher than on placebo after 12 weeks in one trial (not in the diabetic range); the effect in people with diabetes has not been tested
- In a 12-month trial at 2000mg/day, abdominal pain was more common than on placebo (13% vs 5%, not statistically significant); no serious adverse event was attributed to curcumin
- Turmeric and curcumin supplements (not Longvida specifically) have been linked to rare cases of acute liver injury
- In a laboratory study on pig liver cells, curcumin changed the activity of enzymes that clear warfarin; ask a doctor before combining curcumin with an anticoagulant
Cómo tomarlo
Recomendaciones de combinación
Ingredientes que se combinan bien con Curcumin (Longvida) y por qué.
Preguntas frecuentes
Is Longvida the same as turmeric or plain curcumin?
No. Longvida is a specific solid lipid curcumin formulation; 400mg of it provides about 80mg of curcumin. Trials of other curcumin products are not evidence for Longvida, and the Longvida trials are not evidence for them.
What dose was tested?
400mg of Longvida a day (about 80mg curcumin) in the two positive cognition trials. Two trials at 2000mg a day found no cognitive benefit, so a higher dose has not been shown to work better.
Who funded the research?
Verdure Sciences, which makes Longvida, funded the 2020 positive trial. The two trials that found no benefit were funded by the US National Institutes of Health, with capsules supplied by Verdure Sciences. Both positive trials come from one research group and have not been repeated independently.
Is it safe?
The trials reported no serious adverse event attributed to curcumin. One trial found slightly higher fasting blood glucose after 12 weeks, so people with diabetes should ask a doctor first. Turmeric supplements have been linked to rare liver injury, and curcumin may interact with warfarin.
Curcumin (Longvida) en América Latina
Productos disponibles en América Latina
Ninguno de los stacks que hemos auditado figura todavía en nuestro catálogo para América Latina.
ANVISA / COFEPRIS / INVIMA
Nota regulatoria
Esta página es contenido editorial con fines educativos y no constituye consejo médico. Los suplementos alimenticios están regulados por agencias nacionales: la Agência Nacional de Vigilância Sanitária (ANVISA) en Brasil bajo RDC 243/2018, la Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) en México, y el Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) en Colombia. En Argentina, la Disposición 2105/2022 de la Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT) prohíbe siete productos concretos de las marcas Newmind y PURENOOTROPICS (Noopept, F-Phenibut y Bacopa) — no recomendamos productos con Noopept ni F-Phenibut a lectores en Argentina. Aviso para lectores en Brasil: ANVISA publicó en julio de 2026 una alerta oficial advirtiendo que los péptidos inyectables comercializados en línea para bienestar, antienvejecimiento y fitness (incluyendo GHK-Cu, BPC-157, TB-500, CJC-1295 e ipamorelin) no están registrados como medicamentos, suplementos alimentarios ni cosméticos y no pueden venderse legalmente en Brasil. No enlazamos ni recomendamos proveedores que realicen envíos de formulaciones inyectables a Brasil. Consulte siempre a un profesional de la salud calificado antes de comenzar cualquier suplemento. / This page is editorial and not medical advice. Supplements are regulated by national agencies: the Agência Nacional de Vigilância Sanitária (ANVISA) in Brazil, the Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) in Mexico, and the Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) in Colombia. In Argentina, ANMAT Disposition 2105/2022 prohibits seven specific products of the Newmind and PURENOOTROPICS brands (Noopept, F-Phenibut and Bacopa) — we do not recommend products containing Noopept or F-Phenibut to Argentine readers. Brazil notice (updated July 2026): ANVISA issued a formal consumer alert that injectable peptides sold online for wellness, anti-aging, or fitness purposes — including GHK-Cu, BPC-157, TB-500, CJC-1295, and ipamorelin — are unregistered and cannot legally be sold in Brazil. We do not link to or recommend vendors that ship injectable formulations to Brazil. Consult a qualified healthcare professional before starting any supplement.
Fuentes (6)ampliar
- PMID 25277322Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population (2015)
- PMID 32512782Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study (2020)
- PMID 29951592Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults (2018)
- PMID 39199229Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial (2024)
- PMID 32656820Acute liver injury following turmeric use in Tuscany: An analysis of the Italian Phytovigilance database and systematic review of case reports (2021)
- PMID 35695287Curcumin and quercetin modify warfarin-induced regulation of porcine CYP1A2 and CYP3A expression and activity (2022)