Oat Straw Extract
Four small RCTs, all with manufacturer involvement: a 2011 trial (Berry et al.) in elderly people with below-average cognition found a single 1600mg dose reduced Stroop errors, but 2400mg did no better than placebo; a 2012 trial by the same group found 1500mg/day for 12 weeks had no effect on any cognitive measure in healthy older adults (material supplied by Frutarom); a 2015 trial (Kennedy et al., two Frutarom employees as co-authors) found 800mg improved speed, delayed recall and executive function in adults 40–65 with memory complaints, concluding the optimal dose is at or below 800mg; and a 2020 trial (Kennedy et al., two Anklam Extrakt employees as co-authors) found 430–1290mg improved working memory and multitasking over 4 weeks, with no effect on mood. No trial has measured cerebral blood flow.
Evidencia revisada el
Mecanismo de acción
Oat Straw (Avena sativa) extract works primarily by inhibiting phosphodiesterase type 4 (PDE4) and monoamine oxidase B (MAO-B). PDE4 inhibition increases cyclic AMP levels in neurons, enhancing dopaminergic signalling. MAO-B inhibition slows dopamine breakdown. Additionally, oat straw increases nitric oxide production for cerebral vasodilation and contains avenanthramides — unique anti-inflammatory compounds.
Resumen de evidencia clínica
Four small RCTs, all with manufacturer involvement: a 2011 trial (Berry et al.) in elderly people with below-average cognition found a single 1600mg dose reduced Stroop errors, but 2400mg did no better than placebo; a 2012 trial by the same group found 1500mg/day for 12 weeks had no effect on any cognitive measure in healthy older adults (material supplied by Frutarom); a 2015 trial (Kennedy et al., two Frutarom employees as co-authors) found 800mg improved speed, delayed recall and executive function in adults 40–65 with memory complaints, concluding the optimal dose is at or below 800mg; and a 2020 trial (Kennedy et al., two Anklam Extrakt employees as co-authors) found 430–1290mg improved working memory and multitasking over 4 weeks, with no effect on mood. No trial has measured cerebral blood flow.
Matriz de efectos en humanos
Basado solo en ensayos clínicos en humanos. Se excluyen los datos en animales e in vitro.
| Efecto | Evidencia | Magnitud | Estudios |
|---|---|---|---|
| Attention & Concentration | mixta | Pequeño | 4 |
| Stress Response | preliminar | Pequeño | 1 |
Clave de evidencia: Sólida = varios ECA consistentes · Moderada = ECA más pequeños o menos numerosos · Preliminar = ensayos iniciales o n pequeño · Mixta = resultados contradictorios
Beneficios documentados
- Acute attention and executive-function gains in small trials
- Working memory and multitasking over 4 weeks (one trial)
Efectos secundarios y precauciones
- Generally well tolerated — no serious adverse events and no blood-pressure changes in the trials reviewed
- Mild GI discomfort rare
- Oats are often cross-contaminated with gluten during processing — choose a certified gluten-free product if you have celiac disease
Cómo tomarlo
Recomendaciones de combinación
Ingredientes que se combinan bien con Oat Straw Extract y por qué.
Oat Straw supports dopaminergic signalling via MAO-B; Alpha-GPC supports cholinergic signalling. Complementary neurotransmitter coverage for focus.
Both support dopamine availability — Oat Straw by slowing breakdown (MAO-B), Tyrosine by providing precursor.
Oat Straw provides acute attention benefits; Bacopa provides long-term memory consolidation. Covers both short-term and long-term cognitive needs.
Preguntas frecuentes
Is Oat Straw the same as oatmeal?
No. Oat Straw extract comes from the green, unripe aerial parts of Avena sativa — harvested before the oat grain matures. The active compounds (avenanthramides, saponins) are concentrated in the green straw, not the grain. Eating oatmeal does not provide nootropic effects.
Is a higher dose better?
Not in the trials. In Berry 2011, 1600mg reduced Stroop errors but 2400mg did no better than placebo, and Kennedy 2015 concluded the optimal dose was at or below 800mg. Doses of 430–1290mg worked over 4 weeks in Kennedy 2020.
Does Oat Straw contain gluten?
Oats are technically gluten-free but are commonly cross-contaminated with wheat during processing. If you have celiac disease or severe gluten sensitivity, verify the supplement is certified gluten-free or avoid it entirely.
How does it compare to caffeine for focus?
It is not a stimulant, and no trial has compared the two. The oat extract trials found small attention and working-memory gains without the typical stimulant side effects, but the evidence base is four small, manufacturer-linked trials — far thinner than caffeine's.
Principales stacks que contienen Oat Straw Extract
Oat Straw Extract en América Latina
Productos disponibles en América Latina
ANVISA / COFEPRIS / INVIMA
Nota regulatoria
Esta página es contenido editorial con fines educativos y no constituye consejo médico. Los suplementos alimenticios están regulados por agencias nacionales: la Agência Nacional de Vigilância Sanitária (ANVISA) en Brasil bajo RDC 243/2018, la Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) en México, y el Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) en Colombia. En Argentina, la Disposición 2105/2022 de la Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT) prohíbe siete productos concretos de las marcas Newmind y PURENOOTROPICS (Noopept, F-Phenibut y Bacopa) — no recomendamos productos con Noopept ni F-Phenibut a lectores en Argentina. Aviso para lectores en Brasil: el 2 de julio de 2026, ANVISA informó que algunos péptidos inyectables promocionados en internet, entre ellos GHK-Cu, BPC-157, TB-500, CJC-1295 e ipamorelin, no están regularizados en ninguna categoría (alimento, medicamento, cosmético ni suplemento alimentario) y son ilegales para cualquier uso en salud, incluido el estético. No enlazamos ni recomendamos proveedores que realicen envíos de formulaciones inyectables a Brasil. Consulte siempre a un profesional de la salud calificado antes de comenzar cualquier suplemento. / This page is editorial and not medical advice. Supplements are regulated by national agencies: the Agência Nacional de Vigilância Sanitária (ANVISA) in Brazil, the Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) in Mexico, and the Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) in Colombia. In Argentina, ANMAT Disposition 2105/2022 prohibits seven specific products of the Newmind and PURENOOTROPICS brands (Noopept, F-Phenibut and Bacopa) — we do not recommend products containing Noopept or F-Phenibut to Argentine readers. Brazil notice: on 2 July 2026, ANVISA stated that some injectable peptides promoted online, including GHK-Cu, BPC-157, TB-500, CJC-1295 and ipamorelin, are not regularised in any category (food, medicine, cosmetic or food supplement) and are illegal for any health use, including aesthetic use. We do not link to or recommend vendors that ship injectable formulations to Brazil. Consult a qualified healthcare professional before starting any supplement.
Fuentes (4)ampliar
- PMID 21711204Acute effects of an Avena sativa herb extract on responses to the Stroop Color-Word test (2011)
- PMID 22690320Chronic effects of a wild green oat extract supplementation on cognitive performance in older adults: a randomised, double-blind, placebo-controlled, crossover trial (2012)
- PMID 26618715Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial (2015)
- PMID 32485993Acute and Chronic Effects of Green Oat (Avena sativa) Extract on Cognitive Function and Mood during a Laboratory Stressor in Healthy Adults (2020)