Zynamite (Mangifera indica)
The largest and most independent trial (Dodd et al., 2024, n=114, Northumbria University with a PepsiCo co-author) gave a single 300mg dose of mango leaf extract and found no cognitive benefit — participants made more subtraction errors than on placebo. An earlier pilot (López-Ríos et al., 2020, n=16, all four authors Nektium employees) used 500mg, not 300mg, and found only a marginal reaction-time signal. Two sprint trials (2018, 2019; lead authors affiliated with Nektium, the manufacturer) combined 140mg with quercetin or luteolin and improved sprint power output, but measured no cognitive outcome. Three of the four trials are manufacturer-authored.
Evidencia revisada el
Mecanismo de acción
Zynamite is a patented extract of Mangifera indica (mango leaf) standardised to >60% mangiferin. Mangiferin is a potent polyphenol that inhibits catechol-O-methyltransferase (COMT), slowing the breakdown of dopamine and norepinephrine in the prefrontal cortex. This extends the active duration of catecholamines without increasing their production — a unique mechanism distinct from precursor-loading (L-Tyrosine) or synthesis-boosting (caffeine) approaches. Additionally, mangiferin has anti-inflammatory and antioxidant properties.
Resumen de evidencia clínica
The largest and most independent trial (Dodd et al., 2024, n=114, Northumbria University with a PepsiCo co-author) gave a single 300mg dose of mango leaf extract and found no cognitive benefit — participants made more subtraction errors than on placebo. An earlier pilot (López-Ríos et al., 2020, n=16, all four authors Nektium employees) used 500mg, not 300mg, and found only a marginal reaction-time signal. Two sprint trials (2018, 2019; lead authors affiliated with Nektium, the manufacturer) combined 140mg with quercetin or luteolin and improved sprint power output, but measured no cognitive outcome. Three of the four trials are manufacturer-authored.
Matriz de efectos en humanos
Basado solo en ensayos clínicos en humanos. Se excluyen los datos en animales e in vitro.
| Efecto | Evidencia | Magnitud | Estudios |
|---|---|---|---|
| Reaction Time | mixta | Insignificante | 2 |
| Sprint Power Output | preliminar | Pequeño | 2 |
Clave de evidencia: Sólida = varios ECA consistentes · Moderada = ECA más pequeños o menos numerosos · Preliminar = ensayos iniciales o n pequeño · Mixta = resultados contradictorios
Beneficios documentados
- Sprint power output when combined with quercetin or luteolin (manufacturer-authored trials)
- COMT inhibition (mechanism)
Efectos secundarios y precauciones
- Generally well tolerated — no serious adverse events in the four trials reviewed
- Mild GI discomfort rare
- Limited long-term safety data
- MAO inhibitors: theoretical interaction only — mangiferin inhibits COMT rather than MAO, and no clinical reports were found
Cómo tomarlo
Recomendaciones de combinación
Ingredientes que se combinan bien con Zynamite (Mangifera indica) y por qué.
Caffeine increases catecholamine release; Zynamite is proposed to slow their breakdown via COMT inhibition. The combination has not been tested in a cognitive trial.
Tyrosine provides dopamine precursor; Zynamite slows dopamine metabolism. Supply + preservation for sustained catecholamine levels.
L-Theanine is often paired with stimulants, though in a controlled caffeine trial (Rogers 2008) it did not significantly reduce jitteriness, and we cite no trial of L-Theanine with Zynamite.
Preguntas frecuentes
Is Zynamite just mango leaf extract?
Zynamite is a specific patented extract of Mangifera indica standardised to >60% mangiferin. Generic mango leaf supplements may contain far less mangiferin and are not equivalent. The sprint trials name Zynamite; the cognitive trials used mango leaf extract standardised to at least 60% mangiferin.
Is the evidence independent or manufacturer-funded?
Three of the four human trials were authored by Nektium, the manufacturer. The only trial led by an independent academic group (Dodd 2024, n=114) tested the 300mg dose and found no cognitive benefit, with more subtraction errors than placebo.
Can I take Zynamite with caffeine?
No trial has tested Zynamite with caffeine — the sports trials combined it with quercetin or luteolin. If you combine them, monitor your total stimulant load.
Zynamite (Mangifera indica) en América Latina
Productos disponibles en América Latina
Ninguno de los stacks que hemos auditado figura todavía en nuestro catálogo para América Latina.
ANVISA / COFEPRIS / INVIMA
Nota regulatoria
Esta página es contenido editorial con fines educativos y no constituye consejo médico. Los suplementos alimenticios están regulados por agencias nacionales: la Agência Nacional de Vigilância Sanitária (ANVISA) en Brasil bajo RDC 243/2018, la Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) en México, y el Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) en Colombia. En Argentina, la Disposición 2105/2022 de la Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT) prohíbe siete productos concretos de las marcas Newmind y PURENOOTROPICS (Noopept, F-Phenibut y Bacopa) — no recomendamos productos con Noopept ni F-Phenibut a lectores en Argentina. Aviso para lectores en Brasil: el 2 de julio de 2026, ANVISA informó que algunos péptidos inyectables promocionados en internet, entre ellos GHK-Cu, BPC-157, TB-500, CJC-1295 e ipamorelin, no están regularizados en ninguna categoría (alimento, medicamento, cosmético ni suplemento alimentario) y son ilegales para cualquier uso en salud, incluido el estético. No enlazamos ni recomendamos proveedores que realicen envíos de formulaciones inyectables a Brasil. Consulte siempre a un profesional de la salud calificado antes de comenzar cualquier suplemento. / This page is editorial and not medical advice. Supplements are regulated by national agencies: the Agência Nacional de Vigilância Sanitária (ANVISA) in Brazil, the Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) in Mexico, and the Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) in Colombia. In Argentina, ANMAT Disposition 2105/2022 prohibits seven specific products of the Newmind and PURENOOTROPICS brands (Noopept, F-Phenibut and Bacopa) — we do not recommend products containing Noopept or F-Phenibut to Argentine readers. Brazil notice: on 2 July 2026, ANVISA stated that some injectable peptides promoted online, including GHK-Cu, BPC-157, TB-500, CJC-1295 and ipamorelin, are not regularised in any category (food, medicine, cosmetic or food supplement) and are illegal for any health use, including aesthetic use. We do not link to or recommend vendors that ship injectable formulations to Brazil. Consult a qualified healthcare professional before starting any supplement.
Fuentes (4)ampliar
- PMID 32473365Central nervous system activities of extract Mangifera indica L. (2020)
- PMID 38665302Acute effects of mango leaf extract on cognitive function in healthy adults: a randomised, double-blind, placebo-controlled crossover study (2024)
- PMID 31661850A Single Dose of The Mango Leaf Extract Zynamite in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women (2019)
- PMID 29937737Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans (2018)