Dynamine (Methylliberine)
Only three human RCTs have tested methylliberine. The only one measuring cognition with methylliberine alone (La Monica et al., 2023, n=25, 100mg/day) found better self-rated concentration, motivation, mood and energy, but a negligible effect on objective cognitive tests (Stroop, Trail Making B). A 4-week safety trial (VanDusseldorp et al., 2020, n=125, 100–150mg/day) found no clinically significant cardiovascular or blood changes; it did not test cognition. A third trial (Cintineo 2022) tested it only inside a caffeine + theacrine combination. Both methylliberine-specific trials were funded in whole or part by Compound Solutions, which sells Dynamine, and a La Monica co-author holds patents on methylliberine.
Evidencia revisada el
Mecanismo de acción
Dynamine (methylliberine) is a purine alkaloid found in kucha tea leaves, structurally related to caffeine and theacrine. It is described as blocking adenosine receptors (like caffeine) and inhibiting phosphodiesterase. In a 4-week trial at 100–150mg/day it produced no clinically significant changes in heart rate, blood pressure or blood biomarkers. No study has measured tolerance.
Resumen de evidencia clínica
Only three human RCTs have tested methylliberine. The only one measuring cognition with methylliberine alone (La Monica et al., 2023, n=25, 100mg/day) found better self-rated concentration, motivation, mood and energy, but a negligible effect on objective cognitive tests (Stroop, Trail Making B). A 4-week safety trial (VanDusseldorp et al., 2020, n=125, 100–150mg/day) found no clinically significant cardiovascular or blood changes; it did not test cognition. A third trial (Cintineo 2022) tested it only inside a caffeine + theacrine combination. Both methylliberine-specific trials were funded in whole or part by Compound Solutions, which sells Dynamine, and a La Monica co-author holds patents on methylliberine.
Matriz de efectos en humanos
Basado solo en ensayos clínicos en humanos. Se excluyen los datos en animales e in vitro.
| Efecto | Evidencia | Magnitud | Estudios |
|---|---|---|---|
| Subjective Energy | preliminar | Moderado | 1 |
| Focus & Motivation | mixta | Pequeño | 1 |
| Cardiovascular Safety | moderada | Insignificante | 1 |
Clave de evidencia: Sólida = varios ECA consistentes · Moderada = ECA más pequeños o menos numerosos · Preliminar = ensayos iniciales o n pequeño · Mixta = resultados contradictorios
Beneficios documentados
- Better self-rated energy, mood and motivation (one small RCT)
- No clinically significant heart rate or blood pressure change over 4 weeks at 100–150mg
Efectos secundarios y precauciones
- Limited safety data: three human RCTs, both methylliberine-specific trials funded by the manufacturer
- Objective cognition: no measurable effect on Stroop or Trail Making tests in the only trial that tested it
- Mild GI discomfort possible
- Possible interaction with caffeine (additive stimulation)
- Not recommended during pregnancy (precautionary: no pregnancy data)
Cómo tomarlo
Recomendaciones de combinación
Ingredientes que se combinan bien con Dynamine (Methylliberine) y por qué.
A common pairing in pre-formulated stacks. In tactical personnel, 150mg caffeine + 100mg methylliberine + 50mg theacrine matched 300mg caffeine on vigilance reaction time with a smaller diastolic blood pressure rise (Cintineo 2022) — but that tests the combination, not Dynamine alone.
L-Theanine is commonly paired with stimulants for calmer focus, though in a controlled caffeine trial it did not significantly reduce jitteriness, and the combination with Dynamine has not been tested.
Dynamine provides acute adenosine blockade; Zynamite extends dopamine via COMT inhibition.
Preguntas frecuentes
How is Dynamine different from caffeine?
It is a related purine alkaloid, but its evidence base is far thinner: three small human RCTs versus decades of caffeine research. In a 4-week trial at 100–150mg/day it caused no clinically significant heart rate or blood pressure change, and in the one cognition trial it improved self-rated energy and mood but not objective test performance. No trial has compared its onset, duration or sleep effects head-to-head with caffeine.
Does Dynamine build tolerance like caffeine?
Unknown. No study has measured tolerance to methylliberine; the 4-week trial measured safety markers, not whether effects fade. Claims of "minimal tolerance" are not supported by any published trial.
Can I buy Dynamine on its own?
Not easily. Dynamine (methylliberine) is a trademarked ingredient from Compound Solutions and is primarily available in pre-formulated stacks (e.g., Thesis nootropics). Standalone Dynamine capsules are rare on the consumer market.
Is it safe to combine Dynamine with caffeine?
Yes — this is a common combination in performance supplements. Since both block adenosine, the stimulant effects are additive. Keep total combined caffeine + Dynamine intake moderate and monitor for overstimulation (anxiety, restlessness). Start with low doses of each.
Principales stacks que contienen Dynamine (Methylliberine)
Dynamine (Methylliberine) en América Latina
Productos disponibles en América Latina
ANVISA / COFEPRIS / INVIMA
Nota regulatoria
Esta página es contenido editorial con fines educativos y no constituye consejo médico. Los suplementos alimenticios están regulados por agencias nacionales: la Agência Nacional de Vigilância Sanitária (ANVISA) en Brasil bajo RDC 243/2018, la Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) en México, y el Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) en Colombia. En Argentina, la Disposición 2105/2022 de la Administración Nacional de Medicamentos, Alimentos y Tecnología Médica (ANMAT) prohíbe siete productos concretos de las marcas Newmind y PURENOOTROPICS (Noopept, F-Phenibut y Bacopa) — no recomendamos productos con Noopept ni F-Phenibut a lectores en Argentina. Aviso para lectores en Brasil: el 2 de julio de 2026, ANVISA informó que algunos péptidos inyectables promocionados en internet, entre ellos GHK-Cu, BPC-157, TB-500, CJC-1295 e ipamorelin, no están regularizados en ninguna categoría (alimento, medicamento, cosmético ni suplemento alimentario) y son ilegales para cualquier uso en salud, incluido el estético. No enlazamos ni recomendamos proveedores que realicen envíos de formulaciones inyectables a Brasil. Consulte siempre a un profesional de la salud calificado antes de comenzar cualquier suplemento. / This page is editorial and not medical advice. Supplements are regulated by national agencies: the Agência Nacional de Vigilância Sanitária (ANVISA) in Brazil, the Comisión Federal para la Protección contra Riesgos Sanitarios (COFEPRIS) in Mexico, and the Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) in Colombia. In Argentina, ANMAT Disposition 2105/2022 prohibits seven specific products of the Newmind and PURENOOTROPICS brands (Noopept, F-Phenibut and Bacopa) — we do not recommend products containing Noopept or F-Phenibut to Argentine readers. Brazil notice: on 2 July 2026, ANVISA stated that some injectable peptides promoted online, including GHK-Cu, BPC-157, TB-500, CJC-1295 and ipamorelin, are not regularised in any category (food, medicine, cosmetic or food supplement) and are illegal for any health use, including aesthetic use. We do not link to or recommend vendors that ship injectable formulations to Brazil. Consult a qualified healthcare professional before starting any supplement.
Fuentes (3)ampliar
- PMID 37960163Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women (2023)
- PMID 32121218Safety of Short-Term Supplementation with Methylliberine (Dynamine) Alone and in Combination with TeaCrine in Young Adults (2020)
- PMID 36016763Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial (2022)